What SynapseR does at each phase of your study.

Plan is where a clinical question becomes a study. SynapseR walks you through:

• Hypothesis formation with AI-guided PICO / PECO extraction from your research question
• Multi-stage literature search across PubMed with paper-level relevance scoring against your population, intervention, and design
• Endpoint definition with type, domain, instrument, timepoint, and rationale traceable back to your introduction
• R-powered sample size and power analysis using purpose-built scripts for continuous, binary, prevalence, and association designs
• Methods drafting bound to CONSORT for RCTs and STROBE for cross-sectional studies
• Statistical Analysis Plan with estimand, missingness strategy, sensitivity analyses, subgroup specifications, and SHA-256 hash-locking for preregistration
• Pre-results protocol assembly into a clean IMRAD draft

Every artefact is versioned. Every key claim in the draft links back to a paper in your project library.

Prepare is where the study moves from paper to ready-to-run. Planned capabilities:

• Case Report Form (CRF) auto-generated from your locked endpoints
• Participant Information Leaflet rewritten by SynapseR into patient-friendly language while preserving the methodological detail
• Informed consent form templated for your study design and jurisdiction
• Randomisation plan: block, stratified, or simple randomisation, computed in R
• Trial registry submission preparation (ClinicalTrials.gov, EU CTR, ISRCTN as applicable)

Prepare is targeted at clinician-led research that needs ethics submission and site readiness without a full CRO.

Execute is where the study runs. Planned capabilities:

• Live data collection on the CRF you designed in Prepare, integrated with SynapseCPT
• Screening logs and enrolment tracking
• Visit scheduling
• Adverse event capture and reporting
• Site monitoring dashboards

The data layer connects forward to the Publish phase so analysis can run on the actual captured dataset rather than a separate export.

Publish is where data becomes evidence. Planned capabilities:

• Locked SAP runs automatically against the captured dataset, with deviations from the pre-specified plan surfaced explicitly
• CONSORT flow diagram (where applicable)
• Table 1, results section drafted from the actual numbers
• Discussion section grounded in the project's evidence library, with claim-to-paper traceability preserved
• Reference list formatted for the target journal
• Manuscript IMRAD assembly
• Registry results posting

Together, the four phases turn a clinical question into a manuscript that can be defended at every step — from the first PICO to the final figure.